Article
Growth hormone releasing hormone receptor.
Receptors & channels - 1 Jan 2002
Gaylinn Bruce D
Abstract excerpt
Growth hormone releasing hormone receptor (GHRH-R) is a class II G protein-coupled receptor required for normal growth hormone (GH) synthesis and release from the pituitary, and for the normal growth and proliferation of somatotrophs within the pituitary. Mutations of this receptor in mouse and human are associated with GH deficiency, short stature, and pituitary hypoplasia. This signaling system plays important...
Topics
- Animals
- GTP-Binding Proteins
- Genetic Diseases, Inborn
- Growth Hormone-Releasing Hormone
- Humans
- Mice
- Mutation
- Polymorphism, Genetic
- Protein Structure, Tertiary
- Receptors, Neuropeptide
- Receptors, Pituitary Hormone-Regulating Hormone
- Signal Transduction