Article
The macro domain protein family: structure, functions, and their potential therapeutic implications.
Mutation research - 1 Jan 2000
Han Weidong, Li Xiaolei, Fu Xiaobing
Abstract excerpt
Macro domains are ancient, highly evolutionarily conserved domains that are widely distributed throughout all kingdoms of life. The 'macro fold' is roughly 25kDa in size and is composed of a mixed α-β fold with similarity to the P loop-containing nucleotide triphosphate hydrolases. They function as binding modules for metabolites of NAD(+), including poly(ADP-ribose) (PAR), which is synthesized by PAR polymerases...
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