Hydrolase regulates NAD+ metabolites and modulates cellular redox.

Abstract excerpt

Although the classical redox functions of co-enzyme NAD(+) are firmly established in metabolism, there are numerous enzymes that catalyze cleavage of NAD(+) to yield free ADP-ribose (ADPr) or related metabolites, whose functions remain largely unknown. Here we show that the Nudix (nucleoside diphosphate linked to another moiety X) hydrolase Ysa1 from Saccharomyces cerevisiae is a major regulator of cellular ADPr...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Enzymologic
• Share to Glycolysis
• Share to Hydrolases