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Article

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?

Cellular and molecular life sciences : CMLS - 1 Feb 2013

McLennan Alexander G

Abstract excerpt

Many members of the nudix hydrolase family exhibit considerable substrate multispecificity and ambiguity, which raises significant issues when assessing their functions in vivo and gives rise to errors in database annotation. Several display low antimutator activity when expressed in bacterial tester strains as well as some degree of activity in vitro towards mutagenic, oxidized nucleotides such as 8-oxo-dGTP....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23184251
DOI: 10.1007/s00018-012-1210-3
PMCID: PMC11113851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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