Article
The Immunoregulatory Role of Myeloid-Derived Suppressor Cells in the Pathogenesis of Rheumatoid Arthritis.
Frontiers in immunology - 1 Jan 2020
Yan Lan, Liang Mingge, Yang Tong, Ji Jinyu, Jose Kumar Sreena Goutham Sanker, Hou Xiaoqiang, Cao Meiqun, Feng Zhitao
Abstract excerpt
Myeloid-derived suppressor cells (MDSCs) are a group of cells that regulate the immune response and exert immunosuppressive effects on various immune cells. Current studies indicate that MDSCs have both anti-inflammatory effects and proinflammatory effects on rheumatoid arthritis (RA) and RA animal models. MDSCs inhibit CD4+ T cells, which secrete proinflammatory factors such as IFN-γ, IL-2, IL-6, IL-17, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.