Article

Functional Genomics in Human iPSC-Derived Sinoatrial Node Cells Reveals Shared Regulatory Determinants of Heart Rate and Atrial Fibrillation

2023-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Human model systems for functional genomics of heart rhythm are needed to translate genome wide association studies into biological insight and actionable targets. Here we develop a human induced pluripotent stem cell sinoatrial node system that recapitulated the transcriptional and epigenetic heterogeneity of primary human pacemaker tissue, permitting exploration of heart rhythm-associated sing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d0ec69e-7a06-5ba8-886e-9c5c523a9ea3
DOI: 10.1101/2023.07.01.547335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Genomics in Human iPSC-Derived Sinoatrial Node Cells Reveals Shared Regulatory Determinants of Heart Rate and Atrial FibrillationDOI 10.1101/2023.07.01.547335Read

Identification of Functional Variant Enhancers Associated With Atrial FibrillationSemantic proximity Read

Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk AssociationSemantic proximity Read

ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.Semantic proximity Read

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation.Semantic proximity Read

Engineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated CardiomyopathySemantic proximity Read

Genetics and Epigenetics of Atrial FibrillationSemantic proximity Read

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencingSemantic proximity Read

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic AnalysesSemantic proximity Read

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.Semantic proximity Read

Fibrosis, Electrics and GeneticsSemantic proximity Read

An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohortSemantic proximity Read

Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analysesSemantic proximity Read