Article

Integrative genomics of <i>Plasmodium knowlesi</i> reveals parasite-intrinsic regulators of severe human malaria

2026-03-23

Abstract excerpt

To dissect parasite determinants of clinical disease severity in Plasmodium knowlesi , we performed the first integrative genome-wide association (GWAS), transcriptomic, and expression quantitative trait locus (eQTL) analysis from clinical malaria isolates. We identify distinct parasite programs associated with WHO-defined severe disease, characterized by transcriptional activation of stress-response and host–int...

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Literature Corpus work: 4d6fbb24-af9b-5d6a-ad0b-fa318f5d8a0b
DOI: 10.64898/2026.03.22.713451

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