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Carcinogenic bacterial pathogen <i>Helicobacter pylori</i> triggers DNA double-strand breaks and a DNA damage response in its host cells

6 Sept 2011

Abstract excerpt

The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly compromises the genomic integrity of its host cells. We provide evidence that the infection...

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PMID: 21896770
DOI: 10.1073/pnas.1100959108

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