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The landcape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential

24 Feb 2025

Abstract excerpt

BACKGROUND: Helicobacter pylori (H. pylori) infection is a significant risk factor for gastric cancer (GC) development. A growing body of evidence suggests a causal link between infection with H. pylori and increased DNA breakage in the host cells. While several mechanisms have been proposed for this damage, their relative impact on the overall bacterial genotoxicity is unknown. Moreover, the link between the...

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PMID: 39994739
DOI: 10.1186/s13073-025-01439-3

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