Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia regulates allele-specific histone modification of the imprinted H19 gene.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Nov 2020

Moon Yunwon, Kim Ingyum, Chang Soojeong, Park Bongju, Lee Seongyeol, Yoo Seongwook, Chae Sehyun, Hwang Daehee, Park Hyunsung

Abstract excerpt

H19 is a maternally-expressed imprinted gene that encodes long non-coding RNA. Chromatin immunoprecipitation (ChIP)-sequencing analyses of human adipose-derived stem cells (hADSCs) showed that hypoxia induced trimethylation of 4th lysine residue of histone 3 (H3K4me3) in the H19 gene, among the 40 known human imprinted genes, to the greatest extent. We investigated whether hypoxia changed the DNA and histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Methylation

Share to Protein Processing, Post-Translational

Share to RNA, Long Noncoding

Source

Identifiers

PMID: 33035707
DOI: 10.1016/j.bbagrm.2020.194643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia regulates allele-specific histone modification of the imprinted H19 gene.PMID 33035707Read ↗

The genotype and epigenotype synergize to diversify the spatial pattern of expression of the imprinted H19 gene.Semantic proximity Read ↗

The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted H19 locus.Semantic proximity Read ↗

Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.Semantic proximity Read ↗

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis.Semantic proximity Read ↗

A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcriptionSemantic proximity Read ↗

Balancing LncRNA H19 and miR‐675 Bioconversion as a Key Regulator of Embryonic Myogenesis Under Maternal ObesitySemantic proximity Read ↗

H19 lncRNA: Roles in tumorigenesis.Semantic proximity Read ↗

Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction.Semantic proximity Read ↗

Establishment of functional imprinting of the H19 gene in human developing placentae.Semantic proximity Read ↗

The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic InterventionSemantic proximity Read ↗

The effects of placental long noncoding RNA H19 polymorphisms and promoter methylation on H19 expression in association with preeclampsia susceptibility.Semantic proximity Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.