Article
The genotype and epigenotype synergize to diversify the spatial pattern of expression of the imprinted H19 gene.
Mechanisms of development - 1 Apr 1999
Lin W L, He X B, Svensson K, Adam G, Li Y M, Tang T W, Paldi A, Pfeifer S, Ohlsson R
Abstract excerpt
Little is known of how the genetic background effects the phenomenon of genomic imprinting. The H19 gene belongs to a cluster of imprinted genes on human chromosome 11. Here we show that the alternative splicing of a human H19 transcript is genotype-specific. Moreover, this variant transcript, which lacks exon 4, is either not found at all, is widely expressed or is confined to extra-villous cytotrophoblasts in...
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