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Article

Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction.

Placenta - 1 Jan 2011

Koukoura O, Sifakis S, Zaravinos A, Apostolidou S, Jones A, Hajiioannou J, Widschwendter M, Spandidos D A

Abstract excerpt

The expression of imprinted genes is regulated by epigenetic modifications, such as DNA methylation. Many imprinted genes are expressed in the placenta and affect nutrient transfer capacity of the placental exchange barrier. The H19 gene is abundantly expressed by the human placenta and is implicated in the pathogenesis of congenital growth disorders such as Beckwith-Wiedemann (BWS) and Silver-Russell (SRS)...

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Identifiers

PMID: 21129773
DOI: 10.1016/j.placenta.2010.10.017

Genes

FGR

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Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction.PMID 21129773Read ↗

Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2Semantic proximity Read ↗

Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae.Semantic proximity Read ↗

Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity.Semantic proximity Read ↗

Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.Semantic proximity Read ↗

Decreased Placental Methylation at the H19/IGF2 Imprinting Control Region is Associated with Normotensive Intrauterine Growth Restriction but not PreeclampsiaSemantic proximity Read ↗

The H19 Gene Imprinting in Normal Pregnancy and Pre-eclampsiaSemantic proximity Read ↗

Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions†Semantic proximity Read ↗

H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restrictionSemantic proximity Read ↗

Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR)Semantic proximity Read ↗

Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation.Semantic proximity Read ↗

Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype.Semantic proximity Read ↗

Establishment of functional imprinting of the H19 gene in human developing placentae.Semantic proximity Read ↗

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