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Article

Landscape of circulating tumour DNA in metastatic breast cancer.

EBioMedicine - 1 Aug 2020

Davis Andrew A, Jacob Saya, Gerratana Lorenzo, Shah Ami N, Wehbe Firas, Katam Neelima, Zhang Qiang, Flaum Lisa, Siziopikou Kalliopi P, Platanias Leonidas C, Gradishar William J, Behdad Amir, Cristofanilli Massimo

Abstract excerpt

BACKGROUND: We describe the genomic landscape of circulating tumour DNA (ctDNA) across pathological subtypes of metastatic breast cancer. METHODS: 255 clinically annotated patients with ctDNA testing by Guardant360 were stratified into HR+, HER2+, and TNBC cohorts. Frequency and heterogeneity of alterations were reported. Paired ctDNA and tissue sequencing were compared for a subset of patients. The association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32707446
DOI: 10.1016/j.ebiom.2020.102914
PMCID: PMC7381501

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