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Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

17 May 2019

Abstract excerpt

BACKGROUND: Gene variants are dependable and sensitive biomarkers for target-specific therapies in breast cancer (BC). However, detection of mutations within tissues has many limitations. Plasma circulating free DNA (cfDNA) has been reported in many studies as an alternative tool for detection of mutations. But the diagnostic accuracy of cfDNA for most mutations in BC needs to be reviewed. This study was designed...

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PMID: 31101027
DOI: 10.1186/s12885-019-5698-x

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