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Article

Polymerase Fidelity Contributes to Foot-and-Mouth Disease Virus Pathogenicity and Transmissibility In Vivo.

Journal of virology - 9 Dec 2020

Li Chen, Shi Jiabao, Wang Haiwei, Rivera-Serrano Efraín E, Yang Decheng, Zhou Guohui, Sun Chao, Cameron Craig E, Yu Li

Abstract excerpt

The low fidelity of foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase allows FMDV to exhibit high genetic diversity. Previously, we showed that the genetic diversity of FMDV plays an important role in virulence in suckling mice. Here, we mutated the amino acid residue Phe257, located in the finger domain of FMDV polymerase and conserved across FMDV serotypes, to a cysteine (F257C) to study the...

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Identifiers

PMID: 33028719
DOI: 10.1128/JVI.01569-20
PMCID: PMC7737748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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