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Article

Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation.

Virology - 1 May 2018

Li Chen, Wang Haiwei, Yuan Tiangang, Woodman Andrew, Yang Decheng, Zhou Guohui, Cameron Craig E, Yu Li

Abstract excerpt

Previous studies have shown that the FMDV Asia1/YS/CHA/05 high-fidelity mutagen-resistant variants are attenuated (Zeng et al., 2014). Here, we introduced the same single or multiple-amino-acid substitutions responsible for increased 3Dpol fidelity of type Asia1 FMDV into the type O FMDV O/YS/CHA/05 infectious clone. The rescued viruses O-DA and O-DAMM are lower replication fidelity mutants and showed an...

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Identifiers

PMID: 29455065
DOI: 10.1016/j.virol.2018.01.030
PMCID: PMC5911202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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