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Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity

18 May 2017

Abstract excerpt

ABSTRACT Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D pol ) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allow FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D pol in combination with previously reported results from similar picornaviral polymerases to design point...

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PMID: 28515297
DOI: 10.1128/jvi.00081-17

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