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Article

Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence.

Journal of virology - 1 Apr 2014

Zeng Jianxiong, Wang Haiwei, Xie Xiaochun, Li Chen, Zhou Guohui, Yang Decheng, Yu Li

Abstract excerpt

UNLABELLED: Mutagenic nucleoside analogues can be used to isolate RNA virus high-fidelity RNA-dependent RNA polymerase (RdRp) variants, the majority of which are attenuated in vivo. However, attenuated foot-and-mouth disease virus (FMDV) high-fidelity RdRp variants have not been isolated, and the correlations between RdRp fidelity and virulence remain unclear. Here, the mutagen ribavirin was used to select a...

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Identifiers

PMID: 24453363
DOI: 10.1128/JVI.03594-13
PMCID: PMC3993757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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