Article
Sickle cell disease: a malady beyond a hemoglobin defect in cerebrovascular disease.
Expert review of hematology - 1 Jan 2018
Ansari Junaid, Moufarrej Youmna E, Pawlinski Rafal, Gavins Felicity N E
Abstract excerpt
INTRODUCTION: Sickle cell disease (SCD) is a devastating monogenic disorder that presents as a multisystem illness and affects approximately 100,000 individuals in the United States alone. SCD management largely focuses on primary prevention, symptomatic treatment and targeting of hemoglobin polymerization and red blood cell sickling. Areas covered: This review will discuss the progress of SCD over the last few...
Topics
- Anemia, Sickle Cell
- Antisickling Agents
- Cell Communication
- Cerebrovascular Disorders
- Disease Progression
- Glutamine
- Hemoglobins
- Humans
- Hydroxyurea
- Inflammation
- Mutation
- Neutrophils
- Quality of Life