Article
Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.
British journal of clinical pharmacology - 1 Apr 2021
Francke Marith I, Hesselink Dennis A, Li Yi, Koch Birgit C P, de Wit Lucia E A, van Schaik Ron H N, Yang Lin, Baan Carla C, van Gelder Teun, de Winter Brenda C M
Abstract excerpt
AIMS: Tacrolimus is a critical dose drug and to avoid under- and overexposure, therapeutic drug monitoring is standard practice. However, rejection and drug-related toxicity occur despite whole-blood tacrolimus pre-dose concentrations ([Tac]blood ) being on target. Monitoring tacrolimus concentrations at the target site (within peripheral blood mononuclear cells; [Tac]cells ) may better correlate with...
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