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Article

Pharmacogenetic-Whole blood and intracellular pharmacokinetic-Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients.

PloS one - 1 Jan 2020

Tron Camille, Woillard Jean-Baptiste, Houssel-Debry Pauline, David Véronique, Jezequel Caroline, Rayar Michel, Balakirouchenane David, Blanchet Benoit, Debord Jean, Petitcollin Antoine, Roussel Mickaël, Verdier Marie-Clémence, Bellissant Eric, Lemaitre Florian

Abstract excerpt

Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and intracellular exposures as well as the pharmacokinetic-pharmacodynamic relationship of TAC in both compartments. Complete pharmacokinetic profiles (Predose, and 20 min, 40 min, 1h, 2h, 3h, 4h, 6h, 8h, 12h post drug...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppression Therapy

Share to Immunosuppressive Agents

Share to Leukocytes, Mononuclear

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Identifiers

PMID: 32163483
DOI: 10.1371/journal.pone.0230195
PMCID: PMC7067455

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