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Article

ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach.

Clinical chemistry and laboratory medicine - 1 Sept 2015

Tavira Beatriz, Gómez Juan, Diaz-Corte Carmen, Suarez Beatriz, Coronel Diego, Arias Manuel, López-Larrea Carlos, Iglesias Sara, Alonso Belén, Rodrigo Emilio, Coto Eliecer

Abstract excerpt

BACKGROUND: A CYP3A5 gene polymorphism is the main determinant of Tacrolimus (Tac) dose requirements among renal transplanted patients. In spite of the utility of CYP3A5 genotyping to predict the Tac-dose, many patients exhibit an out of range blood Tac level and it is thus likely that other genes/polymorphisms contribute to define Tac bioavailability. To address this issue we searched for coding sequence...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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Share to Kidney Transplantation

Share to Mutation, Missense

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Source

Identifiers

PMID: 25781547
DOI: 10.1515/cclm-2014-1195

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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