The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.

doi:10.1016/j.ijrobp.2017.03.030

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Article

The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.

International journal of radiation oncology, biology, physics - 1 Aug 2017

Sperduto Paul W, Jiang Wen, Brown Paul D, Braunstein Steve, Sneed Penny, Wattson Daniel A, Shih Helen A, Bangdiwala Ananta, Shanley Ryan, Lockney Natalie A, Beal Kathryn, Lou Emil, Amatruda Thomas, Sperduto William A, Kirkpatrick John P, Yeh Norman, Gaspar Laurie E, Molitoris Jason K, Masucci Laura, Roberge David, Yu James, Chiang Veronica, Mehta Minesh

Abstract excerpt

PURPOSE: Brain metastases are a common problem in patients with melanoma, but little is known about the effect of gene mutations on survival in these patients. METHODS AND MATERIALS: We created a retrospective multi-institutional database of 823 patients with melanoma and brain metastases diagnosed between 2006 and 2015. Clinical parameters, gene mutation status (BRAF, C-KIT, NRAS), and treatment were correlated...

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Identifiers

PMID: 28721890
DOI: 10.1016/j.ijrobp.2017.03.030
PMCID: PMC6925531

Genes

BRAF
KIT
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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