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Genetic Alterations of Melanoma Brain Metastases: A Systematic Review and Meta-Analysis.

Molecular diagnosis & therapy - 1 Jan 2023

Pala Laura, Bagnardi Vincenzo, Tettamanzi Francesca, Barberis Massimo, Mazzarol Giovanni, Casali Cecilia, De Pas Tommaso, Pennacchioli Elisabetta, Coppola Sara, Baldini Federica, Cocorocchio Emilia, Ferrucci Pierfrancesco, Patane' Damiano, Saponara Maristella, Queirolo Paola, Conforti Fabio

Abstract excerpt

BACKGROUND: Data on molecular alterations harbored by melanoma brain metastases (MBMs) are limited, and this has hampered the development of more effective therapeutic strategies. We conducted a systematic review and meta-analysis of all the studies reporting DNA sequencing data of MBMs, in order to identify recurrently mutated genes and molecular pathways significantly enriched for genetic alterations. METHODS:...

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PMID: 36401787
DOI: 10.1007/s40291-022-00623-0

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