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Article

Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2020

Mor Danielle E, Sohrabi Salman, Kaletsky Rachel, Keyes William, Tartici Alp, Kalia Vrinda, Miller Gary W, Murphy Coleen T

Abstract excerpt

Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood. We recently discovered a potential causal link between the branched-chain amino acid transferase BCAT-1 and the neurodegenerative movement disorder Parkinson's disease (PD). RNAi-mediated knockdown of Caenorhabditis elegans bcat-1 is known to recapitulate PD-like features,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33024014
DOI: 10.1073/pnas.2009838117
PMCID: PMC7585014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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