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Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease

1 Jan 2020

Abstract excerpt

Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson's disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies of PD patient brains and the use of complex I inhibitors to model the disease previously suggested a reduction in mitochondrial activity as a causative factor in PD, but this may represent an endpoint in the disease...

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PMID: 33178902
DOI: 10.1016/j.tma.2020.07.007

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