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Article

HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond.

PLoS pathogens - 1 Sept 2024

Zhang Yuepeng, Otte Fabian, Stoeckle Marcel, Thielen Alexander, Däumer Martin, Kaiser Rolf, Kusejko Katharina, Metzner Karin J, Klimkait Thomas

Abstract excerpt

Even during extended periods of effective immunological control, a substantial dynamic of the viral genome can be observed in different cellular compartments in HIV-1 positive individuals, indicating the persistence of active viral reservoirs. To obtain further insights, we studied changes in the proviral as well as in the viral HIV-1 envelope (Env) sequence along with transcriptional, translational and viral...

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Anti-Retroviral Agents
CD4-Positive T-Lymphocytes
Genetic Variation
HIV-1
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocyte Subsets

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PMID: 39292732
DOI: 10.1371/journal.ppat.1012526
PMCID: PMC11410260

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