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G3BP1 controls the senescence-associated secretome and its impact on cancer progression

5 Oct 2020

Abstract excerpt

Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its benefits are still elusive. Here, we show that the rasGAP SH3-binding protein 1 (G3BP1) is required for the activation of the senescent-associated secretory phenotype...

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PMID: 33020468
DOI: 10.1038/s41467-020-18734-9

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