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Article

Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals.

Human brain mapping - 1 Jan 2021

Martí-Juan Gerard, Sanroma-Guell Gerard, Cacciaglia Raffaele, Falcon Carles, Operto Grégory, Molinuevo José Luis, González Ballester Miguel Ángel, Gispert Juan Domingo, Piella Gemma

Abstract excerpt

The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including atrophy of the hippocampus, which is one of the brain structures that is early affected by AD. In this work we analyzed the impact of APOE ε4 gene dose and its association with age, on hippocampal...

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Identifiers

PMID: 33017488
DOI: 10.1002/hbm.25202
PMCID: PMC7721244

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