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Article

Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study.

PloS one - 1 Jan 2016

Li Bolun, Shi Jie, Gutman Boris A, Baxter Leslie C, Thompson Paul M, Caselli Richard J, Wang Yalin

Abstract excerpt

The apolipoprotein E (APOE) e4 genotype is a powerful risk factor for late-onset Alzheimer's disease (AD). In the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, we previously reported significant baseline structural differences in APOE e4 carriers relative to non-carriers, involving the left hippocampus more than the right--a difference more pronounced in e4 homozygotes than heterozygotes. We now...

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Identifiers

PMID: 27065111
DOI: 10.1371/journal.pone.0152901
PMCID: PMC4827849

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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