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Article

Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.

The Journal of biological chemistry - 11 Dec 2020

Coggins Si'Ana A, Kim Dong-Hyun, Schinazi Raymond F, Desrosier Ronald C, Kim Baek

Abstract excerpt

HIV Type 1 (HIV-1) and simian immunodeficiency virus (SIV) display differential replication kinetics in macrophages. This is because high expression levels of the active host deoxynucleotide triphosphohydrolase sterile α motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) deplete intracellular dNTPs, which restrict HIV-1 reverse transcription, and result in a restrictive infection in this...

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Identifiers

PMID: 33008888
DOI: 10.1074/jbc.RA120.015273
PMCID: PMC7863885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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