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Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

20 Oct 2015

Abstract excerpt

Among lentiviruses, HIV Type 2 (HIV-2) and many simian immunodeficiency virus (SIV) strains replicate rapidly in non-dividing macrophages, whereas HIV Type 1 (HIV-1) replication in this cell type is kinetically delayed. The efficient replication capability of HIV-2/SIV in non-dividing cells is induced by a unique, virally encoded accessory protein, Vpx, which proteasomally degrades the host antiviral restriction...

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PMID: 26483545
DOI: 10.1074/jbc.m115.691576

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Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding LentivirusesPMID 26483545Read ↗

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