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Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

22 Feb 2017

Abstract excerpt

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT. The accessory lentiviral protein...

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PMID: 28228523
DOI: 10.1073/pnas.1613635114

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