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Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts

4 Sept 2018

Abstract excerpt

T cells and nondividing myeloid cells, and the infected myeloid cells serve as long-living viral reservoirs. Host sterile alpha motif- and histidine-aspartate domain-containing protein 1 (SAMHD1) kinetically restricts reverse transcription of primate lentiviruses, including human immunodeficiency virus, type 1 (HIV-1) and simian immunodeficiency virus (SIV), in nondividing myeloid cells. SAMHD1 enforces this...

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PMID: 30181218
DOI: 10.1074/jbc.ra118.004567

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