Article
Mutations in domain IV of elongation factor EF-G confer -1 frameshifting.
RNA (New York, N.Y.) - 1 Jan 2021
Niblett Dustin, Nelson Charlotte, Leung Calvin S, Rexroad Gillian, Cozy Jake, Zhou Jie, Lancaster Laura, Noller Harry F
Abstract excerpt
A recent crystal structure of a ribosome complex undergoing partial translocation in the absence of elongation factor EF-G showed disruption of codon-anticodon pairing and slippage of the reading frame by -1, directly implicating EF-G in preservation of the translational reading frame. Among mutations identified in a random screen for dominant-lethal mutations of EF-G were a cluster of six that map to the tip of...
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