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Article

Ultrasensitive Detection of Multiplexed Somatic Mutations Using MALDI-TOF Mass Spectrometry.

The Journal of molecular diagnostics : JMD - 1 Jan 2016

Mosko Michael J, Nakorchevsky Aleksey A, Flores Eunice, Metzler Heath, Ehrich Mathias, van den Boom Dirk J, Sherwood James L, Nygren Anders O H

Abstract excerpt

Multiplex detection of low-frequency mutations is becoming a necessary diagnostic tool for clinical laboratories interested in noninvasive prognosis and prediction. Challenges include the detection of minor alleles among abundant wild-type alleles, the heterogeneous nature of tumors, and the limited amount of available tissue. A method that can reliably detect minor variants <1% in a multiplexed reaction using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26596526
DOI: 10.1016/j.jmoldx.2015.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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