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Identification of PDLIM1 as a glioblastoma stem cell marker driving tumorigenesis and chemoresistance

15 Nov 2024

Abstract excerpt

Glioblastoma (GBM) is an aggressive brain tumor with a poor prognosis, largely due to the presence of glioblastoma stem cells (GSCs). These cells drive tumor progression, recurrence, and chemoresistance, making them critical targets for therapy. This study aims to identify novel GSC markers for improved diagnosis and targeted treatment. We utilized single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data to...

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PMID: 39548074
DOI: 10.1038/s41420-024-02241-7

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