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Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.

Molecular biology and evolution - 1 Jul 2025

Lai Dingwang, Qu Xiaolu, Wang Zhen, He Sang, Li Xingzheng, Bao Qi, Sun Guangming, Zhang Jian, Zhu Yanbin, Yi Guoqiang

Abstract excerpt

The Qinghai-Tibet Plateau, characterized by its extreme environmental conditions, presents significant challenges to life, making it an ideal region for studying adaptation and evolution. Tibetan pigs, known for their high genetic diversity and exceptional adaptability to high altitudes, serve as excellent models for investigating high-altitude adaptation. While previous studies have extensively identified...

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Identifiers

PMID: 40644385
DOI: 10.1093/molbev/msaf169
PMCID: PMC12290512

Genes

CFD
EPAS1
KLF13
SPRED1

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Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.PMID 40644385Read ↗

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