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Article

Sirt1/FoxO1-Associated MAO-A Upregulation Promotes Depressive-Like Behavior in Transgenic Mice Expressing Human A53T α-Synuclein.

ACS chemical neuroscience - 18 Nov 2020

Li Yong, Jiao Qian, Du Xixun, Jiang Hong

Abstract excerpt

Nonmotor symptoms are of pivotal importance in Parkinson's disease (PD), among which depressive disorder occurs in more than 45% of PD cases. Decreased levels of noradrenaline (NA) and serotonin (5-HT) in the central nervous system are relevant to it; however, the underlying mechanism is largely unknown. To this end, we conducted behavioral assays to analyze the depressive phenotype in transgenic mice with...

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PMID: 33155799
DOI: 10.1021/acschemneuro.0c00628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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