Article
Genomic insights into low-level rifampicin resistance mediated by borderline rpoB mutations in Mycobacterium tuberculosis: prevalence and phylogeny in Northeast China.
Microbiology spectrum - 1 Sept 2026
Li Lingling, Zhang Mingjin, Su Lin, Qin Xiaoting, Liu Huiying, Zhang Xue, Liu Kewei, Sun Xuejuan, Yan Feng
Abstract excerpt
The emergence of low-level rifampicin (RIF) resistance in Mycobacterium tuberculosis poses a challenge to tuberculosis (TB) control, as it often leads to discordance between genotypic resistance detected by molecular assays (e.g., Xpert MTB/RIF) and phenotypic susceptibility in conventional drug susceptibility testing (DST). In this study, we performed whole-genome sequencing (WGS) on 17 clinical isolates from...
Read the complete abstract on PubMedTopics
- Mycobacterium tuberculosis
- Rifampin
- China
- DNA-Directed RNA Polymerases
- Humans
- Microbial Sensitivity Tests