Article
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
The Lancet. Microbe - 1 Sept 2022
Finci Iris, Albertini Audrey, Merker Matthias, Andres Sönke, Bablishvili Nino, Barilar Ivan, Cáceres Tatiana, Crudu Valeriu, Gotuzzo Eduardo, Hapeela Nchimunya, Hoffmann Harald, Hoogland Christine, Kohl Thomas A, Kranzer Katharina, Mantsoki Anna, Maurer Florian P, Nicol Mark P, Noroc Ecaterina, Plesnik Sara, Rodwell Timothy, Ruhwald Morten, Savidge Theresa, Salfinger Max, Streicher Elizabeth, Tukvadze Nestani, Warren Robin, Zemanay Widaad, Zurek Anna, Niemann Stefan, Denkinger Claudia M
Abstract excerpt
BACKGROUND: Whole-genome sequencing (WGS) of Mycobacterium tuberculosis complex has become an important tool in diagnosis and management of drug-resistant tuberculosis. However, data correlating resistance genotype with quantitative phenotypic antimicrobial susceptibility testing (AST) are scarce. METHODS: In a prospective multicentre observational study, 900 clinical M tuberculosis complex isolates were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.