Article
Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126.
Biochemical and biophysical research communications - 20 Aug 2010
Harnprasopwat Ratanakanit, Ha Daon, Toyoshima Takae, Lodish Harvey, Tojo Arinobu, Kotani Ai
Abstract excerpt
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the post-transcriptional level. Sequence variations in miRNA genes, including pri-miRNAs, pre-miRNAs and mature miRNAs, could potentially influence the processing and/or target selection of miRNAs. In this study, we have found the single nucleotide polymorphism (SNP) at the twenty-fourth nucleotide (+24) of the mature...
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