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Article

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

Genes & development - 1 Dec 1990

Rothberg J M, Jacobs J R, Goodman C S, Artavanis-Tsakonas S

Abstract excerpt

The Drosophila slit locus encodes a protein with four regions containing tandem arrays of a 24-amino-acid leucine-rich repeat (LRR) with conserved flanking sequences (flank-LRR-flank surrounding these arrays), followed by two regions with epidermal growth factor (EGF)-like repeats. Each of these motifs has been implicated in protein-protein interactions as part of an extracellular domain in a variety of other...

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Identifiers

PMID: 2176636
DOI: 10.1101/gad.4.12a.2169

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.PMID 2176636Read ↗

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Semantic proximity Read ↗

Repellent signaling by Slit requires the leucine-rich repeats.Semantic proximity Read ↗

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

Slit is the midline repellent for the robo receptor in Drosophila.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.Semantic proximity Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells.Semantic proximity Read ↗

Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord.Semantic proximity Read ↗

Control of midline glia development in the embryonic Drosophila CNS.Semantic proximity Read ↗

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.Semantic proximity Read ↗

The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance.Semantic proximity Read ↗

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