Article

The oncogenic fusion protein TAZ-CAMTA1 promotes genomic instability and senescence through hypertranscription

2022-12-02

Abstract excerpt

TAZ-CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ-CAMTA1 initiates tumour formation remains unexplained. To study the oncogenic mechanism leading to EHE initiation, we developed a model system whereby TAZ-CAMTA1 expression is induced by doxycycline in primary endothelial cells. Using this model,...

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Identifiers and source

Literature Corpus work: 1a9d95ba-aaa2-5395-a266-ea11b37f71bd
DOI: 10.1101/2022.12.01.518701

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