Article
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Molecular oncology - 1 Oct 2022
Robles-Valero Javier, Fernández-Nevado Lucía, Cuadrado Myriam, Lorenzo-Martín Luis Francisco, Fernández-Pisonero Isabel, Abad Antonio, Redín Esther, Montuenga Luis, Martín-Zanca Dionisio, Bigas Anna, Mallo Moisés, Dosil Mercedes, Bustelo Xosé R
Abstract excerpt
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall-cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene-edited mouse model that expresses a VAV1 mutant protein that recapitulates the signalling alterations present in the VAV1 mutant subclass most frequently found in tumours. We could not detect any overt...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.