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Article

Association of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: An exploratory study.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2024

Rodríguez-Ramírez Alejandra Monserrat, Cedillo-Ríos Valente, Sanabrais-Jiménez Marco Antonio, Becerra-Palars Claudia, Hernández-Muñoz Sandra, Ortega-Ortíz Hiram, Camarena-Medellin Beatriz

Abstract excerpt

Valproate is among the most prescribed drugs for bipolar disorder; however, 87% of patients do not report full long-term treatment response (LTTR) to this medication. One of valproate's suggested mechanisms of action involves the brain-derived neurotrophic factor (BDNF), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of BDNF in LTTR and its...

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PMID: 37921405
DOI: 10.1002/ajmg.b.32966

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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