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Article

A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1.

Molecular bioSystems - 1 Jul 2014

Besold Angelique N, Amick Deborah L, Michel Sarah L J

Abstract excerpt

The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(II). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction.

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Identifiers

PMID: 24820620
DOI: 10.1039/c4mb00246f
PMCID: PMC4066409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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