Motifs in the histone H3 and H4 and chromatin modifying factors are crucial to regulate the multifactorial zinc response pathway in Saccharomyces cerevisiae.

doi:10.1016/j.abb.2025.110571

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Article

Motifs in the histone H3 and H4 and chromatin modifying factors are crucial to regulate the multifactorial zinc response pathway in Saccharomyces cerevisiae.

Archives of biochemistry and biophysics - 1 Oct 2025

Pal Rajshree, Anand Smriti, Acharjee Santoshi, Anjana Vandana, Thakur Prateeksha, Biswas Ashis, Tomar Raghuvir Singh

Abstract excerpt

Zinc is a trace element that plays a crucial role in regulating various biological processes. To identify the factors involved in maintaining zinc homeostasis, we analysed the growth of histone mutants and gene deletions of chromatin-modifying factors. Growth assays revealed that specific regions and amino acid residues of histones H3 and H4, along with several chromatin-modifying factors, are essential for...

Topics

Saccharomyces cerevisiae
Histones
Zinc
Saccharomyces cerevisiae Proteins
Chromatin
Amino Acid Motifs
Gene Expression Regulation, Fungal
Mutation

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PMID: 40721097
DOI: 10.1016/j.abb.2025.110571

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