Article
A mutation in the Zn-finger of the GAL4 homolog LAC9 results in glucose repression of its target genes.
Nucleic acids research - 25 Feb 1990
Kuger P, Gödecke A, Breunig K D
Abstract excerpt
The transcriptional activator LAC9, a GAL4 homolog of Kluyveromyces lactis which mediates lactose and galactose-dependent activation of genes involved in the utilization of these sugars can also confer glucose repression to those genes. Here we report on the isolation and characterization of LAC9-2, an allele which encodes a glucose-sensitive activator in contrast to the one previously cloned. A single amino acid...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA-Binding Proteins
- Enzyme Repression
- Fungal Proteins
- Galactosidases
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Glucose
- Kluyveromyces
- Metalloproteins