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Article

Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer.

PloS one - 1 Jan 2014

Park So Yeon, Seo An Na, Jung Hae Yoen, Gwak Jae Moon, Jung Namhee, Cho Nam-Yun, Kang Gyeong Hoon

Abstract excerpt

The changes in DNA methylation status in cancer cells are characterized by hypermethylation of promoter CpG islands and diffuse genomic hypomethylation. Alu and long interspersed nucleotide element-1 (LINE-1) are non-coding genomic repetitive sequences and methylation of these elements can be used as a surrogate marker for genome-wide methylation status. This study was designed to evaluate the changes of Alu and...

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Share to Alu Elements
Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Long Interspersed Nucleotide Elements

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Share to Receptor, ErbB-2

Source

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Identifiers

PMID: 24971511
DOI: 10.1371/journal.pone.0100429
PMCID: PMC4074093

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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